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HR2-918-15/Natrix #15 (B3), 185 ml - 0.04 M Magnesium chloride hexahydrate, 0.05 M Sodium cacodylate trihydrate pH 6.0, 5 % v/v (+/-)-2-Methyl-2,4-pentanediol. Please note items from this supplier are non-returnable.
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Potent, selective and irreversible PPARγ antagonist. Blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1µM. Much more potent antagonist than BADGE (ALX-270-353). Can be used to antagonize the effects of PPARγ agonists in a variety of cell types. Alternative name: 2-Chloro-5-nitrobenzanilide. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO (50mg/ml), 100% ethanol (10mg/ml) or dimethyl formamide. Insoluble in water. Long Term Storage: Ambient.
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A bioactive sphingolipid; levels increase time-dependently in a nutrient deprivation-induced necroptosis model in MEF cells; reduced levels in obese patients after chronic exercise correlate with weight and fat loss; higher levels in Parkinson’s disease patients correlate with memory deficits
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A non-hydrolyzable phosphorothioate analog of cAMP that competitively inhibits cAMP-dependent protein kinases (PKA) I and II (IC50s = 12.5 and 4.5 µM, respectively); broadly used in research involving cAMP-dependent signaling in vitro and in vivo
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